We use cryoEM and cryoET to study the structure and function of biomolecules and the architecture of cellular systems. 
Rahman et al Neuron
Ruhl et al Nature Comm 
Maity et al PNAS 

We are studying the role of several proteins involved in tauopathies in the hopes of provide molecular roadmaps for potential therapaeutic interventions for diseases such as FTD.
Chang et al Cell

We are trying to understand fundamental molecular mechanisms of exosome production and capture and to determine the biological significance of exosomes in neurodegenerative disease.
Janas et al BBA Biomem
 Wan et al Comm. Bio

We are investigating the early stages of neurodegeneration in Alzheimer's disease and are interested in the interaction of beta-amyloid with synaptophysin.  
Adams et al Sci Reports
Adams et al Plose ONE 
Arthur & Stowell Structure

Using electron tomography we study the architecture of the chemical synapse in cultured neurons in various states of activation and dysfunction due to disease.
Arthur et al Neuroscience 
Ruhl et al Nature Comm

In collaboration with the Shen lab, we study the molecular mechanisms of synaptic vesicle fusion.
Yu et al PNAS
Rathore et al Cell Reports
Shen et al JBC

We develop a variety of methods for cryoEM such as microfluidics, time resolved cyroEM as well as rapid thermal profiling methods for proteomics.
Ball et al Comm Biology 
Basta et al PNAS 
Yeh et al Acta Cryst D

Coming soon

Comming soon


Room A1B43
1945 Colorado Ave
University of Colorado
Boulder, CO 80309


TEL: 303 735 2983
FAX: 303 492 7744